Recent advances in the transition-metal-catalyzed regioselective approaches to polysubstituted benzene derivatives

The regioselective synthetic approaches to polysubstituted benzenes are carried out by stepwise addition of protected substituents via electrophilic substitution reactions. This review discusses recent advances in this field and focuses on the transition-metal-catalyzed cyclotrimerization and cycloaddition reactions in the regioselective synthesis of polysubstituted benzenes.