Hemodialysis (HD) dose and ultrafiltration rate are associated with survival in pediatric and adolescent patients on chronic HD-a large observational study with follow-up to young adult age

Background Hemodialysis (HD) dose targets and ultrafiltration rate (UFR) limits for pediatric patients on chronic HD are not known and are derived from adults (spKt/V>1.4 and Methods Retrospective analysis on a cohort of patients Results A total of 1780 patients were included (age at the start of HD: 0-12y: n=321, >12-18y: n=1459; median spKt/V=1.55, eKt/V=1.31, Kt/BSA=31.2 L/m.sup.2, UFR=10.6 mL/kg/h). (I) spKt/V1.4-1.6 (P1.6 (P Conclusions Our results suggest usefulness of targeting Kt/BSA>30 L/m.sup.2 for best long-term outcomes, corresponding to spKt/V>1.4 (>12 years) and >1.6 (
Author(s): Verena Gotta [sup.1] , Olivera Marsenic [sup.2] , Andrew Atkinson [sup.1] , Marc Pfister [sup.1] [sup.3] Author Affiliations: (1) grid.6612.3, 0000 0004 1937 0642, Pediatric Pharmacology and Pharmacometrics, University [...]