The c-Jun Amino-Terminal Kinase Pathway Is Preferentially Activated by Interleukin-1 and Controls Apoptosis in Differentiating Pancreatic Β-Cells

To characterize the differentiation events that selectively target insulin-producing cells to interleukin (IL)1Β--induced apoptosis, we studied IL-1Β signaling via mitogen-activated protein kinase (MAPK) and stress-activated protein kinase in 2 pancreatic [...]