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LifeTime and improving European healthcare through cell-based interceptive medicine

Authors :
Rajewsky, Nikolaus
Almouzni, Geneviève
Gorski, Stanislaw A.
Aerts, Stein
Amit, Ido
Bertero, Michela G.
Bock, Christoph
Source :
Nature. November 19, 2020, Vol. 587 Issue 7834, p377, 10 p.
Publication Year :
2020

Abstract

Here we describe the LifeTime Initiative, which aims to track, understand and target human cells during the onset and progression of complex diseases, and to analyse their response to therapy at single-cell resolution. This mission will be implemented through the development, integration and application of single-cell multi-omics and imaging, artificial intelligence and patient-derived experimental disease models during the progression from health to disease. The analysis of large molecular and clinical datasets will identify molecular mechanisms, create predictive computational models of disease progression, and reveal new drug targets and therapies. The timely detection and interception of disease embedded in an ethical and patient-centred vision will be achieved through interactions across academia, hospitals, patient associations, health data management systems and industry. The application of this strategy to key medical challenges in cancer, neurological and neuropsychiatric disorders, and infectious, chronic inflammatory and cardiovascular diseases at the single-cell level will usher in cell-based interceptive medicine in Europe over the next decade. The LifeTime initiative is an ambitious, multidisciplinary programme that aims to improve healthcare by tracking individual human cells during disease processes and responses to treatment in order to develop and implement cell-based interceptive medicine in Europe.<br />Author(s): Nikolaus Rajewsky [sup.1] [sup.2] [sup.3] [sup.4] , Geneviève Almouzni [sup.5] , Stanislaw A. Gorski [sup.1] , Stein Aerts [sup.6] [sup.7] , Ido Amit [sup.8] , Michela G. Bertero [sup.9] [...]

Details

Language :
English
ISSN :
00280836
Volume :
587
Issue :
7834
Database :
Gale General OneFile
Journal :
Nature
Publication Type :
Academic Journal
Accession number :
edsgcl.650829164
Full Text :
https://doi.org/10.1038/s41586-020-2715-9