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Role of Lys 100 in human dihydroorotate dehydrogenase: mutagenesis studies and chemiccal rescue by external amines
- Source :
- Biochemistry. July 11, 2000, Vol. 39 Issue 27, p7990, 8 p.
- Publication Year :
- 2000
-
Abstract
- Results reveal that at least one lysyl residue255 is involved in catalysis of the human dihydroorotate dehydrogenase as shown by chemical mutagenesis. In addition, it is seen that substitution of lysyl100 abolishes the activity and is restored by exogenously added primary amines.
Details
- ISSN :
- 00062960
- Volume :
- 39
- Issue :
- 27
- Database :
- Gale General OneFile
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.63969633