Immunologic and Virologic Effects of Subcutaneous Interleukin 2 in Combination With Antiretroviral Therapy: A Randomized Controlled Trial

Authors :: Davey Jr., Richard T.
Murphy, Robert L.
Graziano, Frank M.
Boswell, Stephen L.
Pavia, Andrew T.
Cancio, Margarita
Nadler, Jeffrey P.
Chaitt, Doreen G.
Dewar, Robin L.
Sahner, David K.
Duliege, Anne-Marie
Capra, William B.
Leong, Wai-Ping
Giedlin, Martin A.
Lane, H. Clifford
Kahn, James O.
Source :: JAMA, The Journal of the American Medical Association. July 12, 2000, Vol. 284 Issue 2, p183
Publication Year :: 2000
Abstract: Combining interleukin 2 (IL-2) with other AIDS drugs appears to be more effective than the AIDS drugs alone. This was the conclusion of researchers who randomly assigned 78 HIV patients to take AIDS drugs only or AIDS drugs plus IL-2. Those who took AIDS drugs plus IL-2 had greater immune recovery and greater viral suppression compared to those who only took AIDS drugs. However, IL-2 caused many side effects and further research is needed to determine whether it will improve survival rates.

Tools