Preventing cytokine storm syndrome in COVID-19 using [alpha]-1 adrenergic receptor antagonists

Authors :: Konig, Maximilian F.
Staedtke, Mike Powell Verena
Bai, Ren-Yuan
Thomas, David L.
Fischer, Nicole
Huq, Sakibul
Khalafallah, Adham M.
Koenecke, Allison
Xiong, Ruoxuan
Mensh, Brett
Papadopoulos, Nickolas
Kinzler, Kenneth W.
Vogelstein, Bert
Vogelstein, Joshua T.
Athey, Susan
Zhou, Shibin
Bettegowda, Chetan
Source :: Journal of Clinical Investigation. July 2020, Vol. 130 Issue 7, p3345, 3 p.
Publication Year :: 2020
Abstract: Dysregulated host immune responses drive mortality in pneumonia and acute respiratory distress syndrome (ARDS) caused by a wide range of infections. In coronavirus disease 2019 (COVID-19), severe acute respiratory syndrome [...]

Subjects :: Johns Hopkins University. School of Medicine
Prevention
Health aspects
Mortality -- China -- United Kingdom -- Maryland
Sarilumab -- Health aspects
Severe acute respiratory syndrome -- Prevention
Coronaviruses -- Health aspects
Cytokines -- Health aspects
Pneumonia -- Prevention
Siltuximab -- Health aspects
Adult respiratory distress syndrome -- Prevention
COVID-19 -- Prevention
Medical schools -- Health aspects
T cells -- Health aspects

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