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The Putative Antiglycation Agent Phenacylthiazolium Bromide Suppresses Cellular Triosephosphate Accumulation in Model Hyperglycaemia In Vitro by Stimulating the Pentosephosphate Pathway to Consume Glyceraldehyde-3-Phosphate and Produce Ribose-5-Phosphate
- Source :
- Diabetes. May 2000, Vol. 49 Issue 5, A150
- Publication Year :
- 2000
-
Abstract
- Three biochemical mechanisms thought to contribute to the development of diabetic complications (activation of protein kinase CΒ activation, metabolic pseudohypoxia, methylglyoxal-mediated advanced glycation) have the accumulation of triosephosphate glycolytic intermediates [...]
Details
- Language :
- English
- ISSN :
- 00121797
- Volume :
- 49
- Issue :
- 5
- Database :
- Gale General OneFile
- Journal :
- Diabetes
- Publication Type :
- Periodical
- Accession number :
- edsgcl.62891842