Myogenic reactivity and resistance distribution in the coronary arterial tree: a model study

Myogenic reactivity and resistance distribution in the coronary arterial tree: a model study. Am J Physiol Heart Circ Physiol 278: H1490-H1499, 2000.--The objectives of this study were to evaluate the myogenic behavior of blood vessels and their interaction within the coronary arterial tree and to evaluate the possible role of the myogenic response in autoregulation. The model consists of 10 compartments in series, each representing a class of vessel sizes. Diameter and resistance in each class are determined by their value at full dilation ([d.sub.p], [R.sub.p]) and by the myogenic response. Three distributions of [R.sub.p] and three distributions of myogenic strength, [M.sub.i] (slope of pressure-diameter curve, range - 0.05 to - 0.4%/mmHg) were evaluated (9 cases). It was found that larger vessels attenuate the myogenic activity of smaller vessels and that myogenic responsiveness is sufficient to achieve autoregulation. When [M.sub.i] has a maximum in vessels of 84 [micro]m, the maximum effect of perfusion pressure on active diameter occurs in vessels between 123 and 181 [micro]m, depending on the distribution of [R.sub.p]. Distribution of resistance and control mechanisms in the coronary arterial tree are important for interpretation of individual vessel responses as observed in vivo. coronary circulation; myogenic response; autoregulation; mathematical model