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Visual Disengagement: Genetic Architecture and Relation to Autistic Traits in the General Population
- Source :
- Journal of Autism and Developmental Disorders. June, 2020, Vol. 50 Issue 6, p2188, 13 p.
- Publication Year :
- 2020
-
Abstract
- Visual disengagement has been hypothesized as an endophenotype for autism. In this study we used twin modelling to assess the role of genetics in basic measures of visual disengagement, and tested their putative association to autistic traits in the general population. We used the Gap Overlap task in a sample of 492 twins. Results showed that most of the covariance among eye movement latencies across conditions was shared and primarily genetic. Further, there were unique genetic contributions to the Gap condition, but not to the Overlap condition-i.e. the one theorized to capture visual disengagement. We found no phenotypic association between autistic traits and disengagement, thus not supporting the hypothesis of visual disengagement as an endophenotype for autistic traits.<br />Author(s): Monica Siqueiros Sanchez [sup.1] [sup.2] , Erik Pettersson [sup.3] , Daniel P. Kennedy [sup.4] , Sven Bölte [sup.1] [sup.2] [sup.5] , Paul Lichtenstein [sup.3] , Brian M. D'Onofrio [sup.3] [...]
- Subjects :
- Medical research -- Physiological aspects
Medicine, Experimental -- Physiological aspects
Ocular manifestations of general diseases -- Genetic aspects -- Risk factors
Phenotype -- Testing -- Physiological aspects -- Genetic aspects
Autism -- Physiological aspects -- Genetic aspects -- Risk factors
Health
Subjects
Details
- Language :
- English
- ISSN :
- 01623257
- Volume :
- 50
- Issue :
- 6
- Database :
- Gale General OneFile
- Journal :
- Journal of Autism and Developmental Disorders
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.625363906
- Full Text :
- https://doi.org/10.1007/s10803-019-03974-6