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Deoxyribonucleoside cyclic N-acylphosphoramidites as a new class of monomers for the stereocontrolled synthesis of oligothymidylyl- and oligodeoxycytidylyl- phosphorothioates

Authors :
Wilk, Andrzej
Grajkowski, Andrzej
Phillips, Lawrence R.
Beaucage, Serge L.
Source :
Journal of the American Chemical Society. March 15, 2000, Vol. 122 Issue 10, p2149, 8 p.
Publication Year :
2000

Abstract

A promising new type of monomer in the P-stereospecific synthesis of PS-ODNs has been found in deoxyribonucleoside cyclic N-acylphosphoramidites such as Rp-1 and Sp-1.

Details

ISSN :
00027863
Volume :
122
Issue :
10
Database :
Gale General OneFile
Journal :
Journal of the American Chemical Society
Publication Type :
Academic Journal
Accession number :
edsgcl.62516120