Back to Search Start Over

Brain structural correlates of alexithymia in patients with major depressive disorder

Authors :
Forster, Katharina
Enneking, Verena
Dohm, Katharina
Redlich, Ronny
Meinert, Susanne
Geisler, Adina Isabel
Leehr, Elisabeth Johanna
Kugel, Harald
Baune, Bernhard T.
Arolt, Volker
Zwitserlood, Pienie
Grotegerd, Dominik
Dannlowski, Udo
Source :
Journal of Psychiatry and Neuroscience. March, 2020, Vol. 45 Issue 2, p117, 8 p.
Publication Year :
2020

Abstract

Background: Alexithymia is a risk factor for major depressive disorder (MDD) and has been associated with diminished treatment response. Neuroimaging studies have revealed structural aberrations of the anterior cingulate cortex and the fusiform gyrus in healthy controls with high levels of alexithymia. The present study tried to corroborate and extend these results to patients with MDD compared with healthy controls. Methods: We investigated the relationship between alexithymia, depression and grey matter volume in 63 patients with MDD (mean age [+ or -] standard deviation = 42.43 yr [+ or -] 11.91; 33 female) and 46 healthy controls (45.35 yr [+ or -] 8.37; 22 female). We assessed alexithymia using the Toronto Alexithymia Scale. We conducted an alexithymia x group analysis of covariance; we used a region-of-interest approach, including the fusiform gyrus and anterior cingulate cortex, and conducted whole brain analysis using voxel-based morphometry. Results: Our analysis revealed a significant alexithymia x group interaction in the fusiform gyrus (left, [p.sub.FWE] = 0.031; right, [p.sub.FWE] = 0.010). Higher alexithymia scores were associated with decreased grey matter volume in patients with MDD ([p.sub.FWE] = 0.009), but with increased grey matter volume of the fusiform gyrus in healthy controls ([p.sub.FWE] = 0.044). We found no significant main effects in the region-of-interest analysis. Limitations: Owing to the naturalistic nature of our study, patients with MDD and healthy controls differed significantly in their alexithymia scores. Conclusion: Our results showed the fusiform gyrus as a correlate of alexithymia. We also found differences related to alexithymia between patients with MDD and healthy controls in the fusiform gyrus. Our study encourages research related to the transition from risk to MDD in people with alexithymia.<br />Introduction Major depressive disorder (MDD) is one of the most common and disabling psychiatric diseases worldwide. (1) At least one-third of patients with MDD do not respond to first-line treatment, [...]

Details

Language :
English
ISSN :
11804882
Volume :
45
Issue :
2
Database :
Gale General OneFile
Journal :
Journal of Psychiatry and Neuroscience
Publication Type :
Academic Journal
Accession number :
edsgcl.617285669
Full Text :
https://doi.org/10.1503/jpn.190044