Scaling-up the manufacture of a topical drug product: a quality by design approach: Topical formulation development is intrinsically complex. With the topical drug delivery market projected to exceed US$125.5 billion globally by 2022, robust supply chains and manufacturing processes will be fundamental to meeting these expectations (1)

Accurate scale-up using a well thought out strategy is a significant aspect of developing a robust manufacturing process for a topical drug formulation. Development programmes often benefit from even modest [...]