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Metabolomic networks connect host-microbiome processes to human Clostridioides difficile infections
- Source :
- Journal of Clinical Investigation. September, 2019, Vol. 129 Issue 9, p3792, 15 p.
- Publication Year :
- 2019
-
Abstract
- Clostridioides difficile infection (CDI) accounts for a substantial proportion of deaths attributable to antibiotic-resistant bacteria in the United States. Although C. difficile can be an asymptomatic colonizer, its pathogenic potential is most commonly manifested in patients with antibiotic-modified intestinal microbiomes. In a cohort of 186 hospitalized patients, we showed that host and microbe-associated shifts in fecal metabolomes had the potential to distinguish patients with CDI from those with non-C. difficile diarrhea and C. difficile colonization. Patients with CDI exhibited a chemical signature of Stickland amino acid fermentation that was distinct from those of uncolonized controls. This signature suggested that C. difficile preferentially catabolizes branched chain amino acids during CDI. Unexpectedly, we also identified a series of noncanonical, unsaturated bile acids that were depleted in patients with CDI. These bile acids may derive from an extended host-microbiome dehydroxylation network in uninfected patients. Bile acid composition and leucine fermentation defined a prototype metabolomic model with potential to distinguish clinical CDI from asymptomatic C. difficile colonization.<br />Introduction Each year in the United States, over 450,000 cases of Clostridioides difficile infection (CDI) are associated with over 29,000 associated deaths, with attributable costs of over $2 billion (1). [...]
- Subjects :
- Hospital patients -- Health aspects
Branched chain amino acids -- Health aspects
Fermentation -- Health aspects
Antibiotics -- Health aspects
Microbial drug resistance -- Health aspects
Infection -- Health aspects
Diarrhea -- Health aspects
Deoxycholic acid -- Health aspects
Amino acids
Bile acids
Bacteria
Health care industry
Subjects
Details
- Language :
- English
- ISSN :
- 00219738
- Volume :
- 129
- Issue :
- 9
- Database :
- Gale General OneFile
- Journal :
- Journal of Clinical Investigation
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.600664915
- Full Text :
- https://doi.org/10.1172/JCI126905