Direct, convergent hypersensitivity of calcium-activated force generation produced by hypertrophic cardiomyopathy mutant alpha-tropomyosins in adult cardiac myocytes

Authors :: Michele, Daniel E.
Albayya, Faris P.
Metzger, Joseph M.
Source :: Nature Medicine. Dec, 1999, Vol. 5 Issue 12, p1413, 5 p.
Publication Year :: 1999
Abstract: Cardiac myocytes that have mutations in the gene for alpha-tropomyosin can produce inappropriate force during conditions of submaximal calcium levels. This indicates that these mutations can cause hypertrophic cardiomyopathy.

Subjects :: Muscle cells -- Physiological aspects
Cardiomyopathy, Hypertrophic -- Research

Tools