The crystal structure of human eukayotic release factor eRF1-mechanism of stop codon recognition and peptidyl-tRNA hydrolysis

Authors :: Song, Haiwei
Mugnier, Pierre
Das, Amit K.
Webb, Helen M.
Evans, David R.
Tuite, Mick F.
Hemmings, A Brian
Barford, David
Source :: Cell. Feb 4, 2000, Vol. 100 Issue 3, p311, 11 p.
Publication Year :: 2000
Abstract: Results indicate that the GGQ sequence motiff on the release factor eRF1 triggers the hydrolytic activity of the peptidyl transferase complex. Data further show that substitutions of glycine residues in the motiff abolishes this activity of the eRF1.

Subjects :: Protein biosynthesis -- Physiological aspects
Transfer RNA -- Physiological aspects
Transferases -- Research
Crystals -- Structure
Biological sciences

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