Two new tailoring enzymes, a glycosyltransferase and an oxygenase, involved in biosynthesis of the angucycline antibiotic urdamycin A in Streptomyces fradiae Tu2717

Results describe the urdamycin biosynthetic gene cluster composition and identify the gene products. The product of urdM exhibits similarities to oxygenase and the amino acid sequence of urdGT2 resembles that of glycosyltransferase. Data further indicate that UrdGT2 catalyzes the earliest glycosyltransfer step in urdamycin biosynthesis.