Oppositely imprinted genes p57(sup)Kip2 and Igf2 interact in a mouse model for Beckwith-Wiedemann syndrome

Authors :: Caspary, Tamara
Cleary, Michele A.
Perlman, Elizabeth J.
Zhang, Pumin
Elledge, Stephen J.
Tilghman, Shirley M.
Source :: Genes & Development. Dec 1, 1999, Vol. 13 Issue 23, p3115, 10 p.
Publication Year :: 1999
Abstract: Results demonstrate that the two linked but unrelated genes p57(sup)Kip2 and Igf2 are involved in the manifestation of Beckwith-Widemann syndrome (BWS) and act antagonistically,indicating that mutations in either gene leads to BWS.

Subjects :: Beckwith-Wiedemann syndrome -- Analysis
Dysplasia -- Genetic aspects
Cleft palate -- Genetic aspects
Genetic disorders -- Research
Biological sciences

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