Mechanism of inhibition of cathepsin K by potent, selective 1,5-diacylcarbohydrazides: a new class of mechanism-based inhibitors of thiol proteases

Authors :: Bossard, Mary J.
Tomaszek, Thaddeus A.
Levy, Mark A.
Ijames, Carl F.
Huddleston, Michael J.
Briand, Jacques
Thompson, Scott
Halpert, Stacie
Veber, Daniel F.
Carr, Steven A.
Meek, Thomas D.
Tew, David G.
Source :: Biochemistry. Nov 30, 1999, Vol. 38 Issue 48, p15893, 10 p.
Publication Year :: 1999
Abstract: 1,5-diacylcarbohydrazides inhibit thiol proteases via the formation of a hydrazide-containing product and a carbamyl-enzyme intermediate. The inhibited enzyme exists in a thioester complex.

Subjects :: Enzyme inhibitors -- Research
Proteases -- Research
Biological sciences
Chemistry

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