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CtBP/BARS induces fission of Golgi membranes by acylating lysophosphatidic acid

Authors :
Weigert, Roberto
Guiseppina Silletta, Maria
Spano, Stefania
Turacchio, Gabriele
Cericola, Claudia
Colanzi, Antonio
Senatore, Silvia
Mancini, Raffaella
Polishchuk, Elene V.
Salmona, Mario
Facchiano, Francesco
Burger, Koert N.J.
Mironov, alexander
Luini, Alberto
Corda, Daniela
Source :
Nature. Nov 25, 1999, Vol. 402 Issue 6760, p429, 5 p.
Publication Year :
1999

Abstract

The CtBP/BARS protein functions in the dynamics of Golgi tubules and is required in the fission machinery operating at Golgi tubular networks. CtBP/BARS is found to use acyl-CoA to selectively catalyze the acylation of lyso-phosphatidic acid to phosphatidic acid in pure lipidic systems as well as in Golgi membranes.

Details

ISSN :
00280836
Volume :
402
Issue :
6760
Database :
Gale General OneFile
Journal :
Nature
Publication Type :
Academic Journal
Accession number :
edsgcl.58342060