Comparative mapping of genes from human chromosome 12 by genetic linkage mapping in cattle

The comparative mapping of genes improves the comprehensiveness of most genetic maps and extends our knowledge of evolutionary history. A new study maps loci from human chromosome 12 in cattle to compare the gene order. It is shown that six cattle loci contain polymorphisms that have previously been mapped in humans. Four loci, LALBA, SYT1, SLC2A3 and TP11, mapped to chromosome 5 in cattle and one, PLA2G1B, mapped to cattle chromosome 17. The study reveals cattle have a lower genetic variation than humans but reveals a potential for the production of millions of single-nucleotide polymorphisms in cattle.