Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex

Key cellular processes like gene transcription and DNA replication are facilitated by eukaryotic chromosomes which undergo dynamic assembly and remodelling. A novel ATP-dependent remodelling activity has been identified, and its functional characteristics have been examined. The complex identified has been described as a nucleosome remodelling and deactylating complex. A functional and physical links has been established between nucleosome remodelling proteins and different histone deacetylase chromatin-modifying activities.