Rad52 protein stimulates DNA strand exchange by Rad51 and replication protein A

Rad52 protein stimulates DNA strand exchange by targeting Rad51 protein to a complex of replication protein A (RPA) with single-stranded DNA. It appears that Rad52 protein facilitates the loading of Rad51 protein onto RPA-single stranded DNA. The activities of Rad52 protein are significant in double-strand DNA break repair and homologous recombination, but they cannot totally account for all the roles of RAD52 in these processes.