Expression of AE2 anion exchange in mouse intestine

The expression of anion exchanger 2 (AE2) mRNA and protein in the mouse intestine was characterized. AE2 mRNA abundance was higher in colon than in more proximal segments. AE2a mRNA was more abundant than AE2b mRNA throughout the intestine, and AE2c mRNA was expressed at very low levels. AE2 polypeptide was more abundant in colonic surface cells than in crypts, while ileal crypts and villi showed similar AE2 abundance. AE2 was also found in mural vascular smooth muscle.