Insulin regulation of glucose transport and phosphorylation in skeletal muscle assessed by PET

In vivo insulin regulation of glucose transport and phosphorylation in skeletal muscle of healthy, lean volunteers was investigated. PET imaging and compartmental modeling of the time course of skeletal muscle uptake and utilization after a bolus injection of deoxy-D-glucose was conducted during metabolic steady-state conditions at four rates of euglycemic insulin infusion. Results showed an essential interaction between transport and phosphorylation in the control of insulin-stimulated glucose metabolism in skeletal muscle.