The gene for leukoencephalopathy with vanishing white matter is located on chromosome 3q27

Leukoencephalopathy with vanishing white matter (VWM), an autosomal recessive disorder with normal early development and childhood-onset neurological deterioration in most cases, is discussed with the information that the gene that is located on chromosome 3q27. It had appeared from genealogical studies that seven parents in four Dutch families with VWM may have inherited a disease allele from a common ancestor at least eight generations back. A genome linkage screening has been carried out for 19 families of varying ethnic origins.