The gene for hypotrichosis of Marie Unna maps between D8S258 and D8S298: exclusion of the hr (ital) gene by cDNA and genomic sequencing

The mappinf of the gene for hypotrichosis of Marie Unna, an autosomal dominant hair-loss disorder with childhood onset, to a locus between D8S258 and D8S298 and exclusion of the hr (ital) gene by genomic and cDNA sequencing are discussed. A genomwide search was carried out in a large Dutch family with 400 fluorescent microsatellite markers used, and a British kindred was analyzed with additional markers in the region.