Stimulation of both aerobic glycolysis and Na+- K+-ATPase activity in skeletal muscle by epinephrine or amylin

The role of Na+-K+-ATPase in increasing the aerobic glycolysis in skeletal muscles has been studied. The effects of epinephrine and amylin on the Na+-K+ pump activity has also been examined. Glycolysis was correlated with the Na+-K+-ATPase activity in resting rat digitorum longus and soleus muscles incubated at 30 degrees C. Results indicate that increasing amounts of epinephrine and amylin increased lactate production three to four times but decreased the intracellular Na+-to-K+ ratio. Glycolysis was suppressed by as much as 70% by ouabain in muscles exposed to epinephrine at high concentrations.