Synthesis of cyclopropyl-fused carbocyclic nucleosides via the regioselective opening of cyclic sulfites

A study presents the results of the cyclopropane-fused alternative using a bicyclo[3.1.0]hexane system to generate analogues of ring-expanded oxetanocins carrying different purine and pyrimidine bases. A cyclic sulfite intermediate was used as an epoxide surrogate to synthesize several cyclopropyl-fused carboxylic nucleosides. The cyclic sulfite used in the study represents a useful option in a general approach to the synthesis of carboxylic nucleosides.