Regulation of Spi 2.1 and 2.2 gene expression after turpentine inflammation: discordant responses to IL-6

The proximal promoters of the genes examined focusing on signal transducer and activation of transcription (STAT) binding sites contained in these promoter elements to investigate the role of STAT proteins in the divergent regulation of the Spi 2.1 and Spi 2.2 genes after induction of acute phase response. Differential regulation of Spi 2.1 and 2.2 genes is partly caused by differences in the promoters of these genes at the gamma-activated sequence sites. Interleukin-6 alone fails to reproduce the pattern of rat Spi 2 gene expression that results from turpentine-induced inflammation.