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The gene for cherubism maps to chromosome 4p16.3
- Source :
- American Journal of Human Genetics. July, 1999, Vol. 65 Issue 1, p151, 7 p.
- Publication Year :
- 1999
-
Abstract
- The gene for cherubism, a rare familial childhood disease that results in prominence of the lower face and a somewhat cherubic look, based on Renaissance art, has been found to map to chromosome 4p16.3. The gene is in a 3-cM interval between D4S127 (ital) and 4p-telomere with a strong candidate the gene for fibroblast growth factor receptor 3 (FGR3(ital)). A genomewide linkage search has been carried out using two families with radiologically, clinically and/or histologically confirmed cherubism. Many cases are inherited autosomal dominantly, but there are cases where no family history has been reported.
Details
- ISSN :
- 00029297
- Volume :
- 65
- Issue :
- 1
- Database :
- Gale General OneFile
- Journal :
- American Journal of Human Genetics
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.55226552