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Rethinking peritubular capillary basement membrane multilayering in renal transplant pathology: a case report
- Source :
- Pediatric Nephrology. April, 2017, Vol. 32 Issue 4, p697, 5 p.
- Publication Year :
- 2017
-
Abstract
- Background Severe multilayering (ML) of the peritubular capillary basement membranes in kidney allografts is considered to be an ultrastructural hallmark of chronic antibody-mediated rejection (CAMR). We describe here the unexpected findings in a young male adolescent with underlying focal segmental glomerulosclerosis who underwent a living-related donor transplant procedure, a case which brought into question the specificity of ML. Methods The patient received a kidney from his mother, whose donor screening was unremarkable. He developed nephrotic-range proteinuria shortly after the procedure. Biopsies performed within the first 6 months after transplantation demonstrated ML (5-6 layers). Results Since there were no other criteria for CAMR, electron microscopic analysis of the baseline biopsy was performed, which in retrospect also demonstrated ML. The donor is still asymptomatic after 7 years of follow-up, with normal renal function and no proteinuria. Conclusions We discuss the phenomenon of ML in renal disease and together with the findings in our case would like to draw attention to the fact that ML in the setting of renal transplantation is not specific to CAMR, as it can exist in several kidney diseases and even in asymptomatic donors.<br />Author(s): Diana Maria Lopategui [sup.1] [sup.2] , Evelyne Lerut [sup.3] , Maarten Naesens [sup.4] [sup.5] , Rita Van Damme-Lombaerts [sup.2] , Elena Levtchenko [sup.2] , Noël Knops [sup.2] Author Affiliations: [...]
- Subjects :
- Health
Subjects
Details
- Language :
- English
- ISSN :
- 0931041X
- Volume :
- 32
- Issue :
- 4
- Database :
- Gale General OneFile
- Journal :
- Pediatric Nephrology
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.551026162
- Full Text :
- https://doi.org/10.1007/s00467-016-3541-z