Creatine supplementation differentially affects maximal isometric strength and time to fatigue in large and small muscle groups

Creatine (CR) supplementation seems to increase time to fatigue and maximal strength in isometric exercise, but only for movements performed with a large muscle mass. CR supplementation affects time to fatigue and maximal isometric strength in small and large muscle groups differently based on data from a double-blind study. Supplementation significantly increased maximal isometric strength in knee extension, but not in handgrip exercise. Supplementation increased time to fatigue in each of the three bouts of submaximal knee extension and handgrip exercise vs the placebo trials.