X-linked late-onset sensorineural deafness caused by a deletion involving OA1 and a novel gene containing WD-40 repeats

A new gene, termed transducin beta-like 1 or TBL1, has been isolated that appears to be involved in X-linked late-onset sensironeural deafness associated with ocular albinism. TBL1 has 18 exons covering about 150 kb in the Xp22.3 region next to the ocular albinism gene (OA1). The new gene has characteristics that place it in the WD-40-repeat protein family.