Relationship between fresh frozen plasma to packed red blood cell transfusion ratio and mortality in cardiovascular surgery

Purpose The aim of this study was to examine the relationship between FFP (fresh frozen plasma)/pRBC (packed red blood cell) transfusion ratio and outcomes in patients undergoing cardiovascular surgery. Methods This is a single center retrospective cohort study performed in a cardiovascular center. Patients undergoing cardiovascular surgery between January 2012 and October 2016 with or without massive transfusion (n = 1453). Patients' outcomes were compared based on FFP/pRBC transfusion ratio (FFP/pRBC > 1 or FFP/pRBC [less than or equal to] 1). Results In hospital mortality and rate of stroke and myocardial infarction was significantly higher in patients with less than 1 of FFP/pRBC transfusion ratio only in patients with massive transfusion (3.0 vs 8.8%, p = 0.001; 0.7 vs 6.4%, p < 0.001; 1.0 vs 3.2%, p = 0.047, respectively). Conclusions Higher FFP/RBC ratio was associated with reduced risk of death, stroke and myocardial infarction only in patients with cardiovascular surgery receiving massive transfusion. Clinicians should be aware that judicious FFP replacement plays a critical role in the successful management of massive transfusion in cardiac surgery.
Author(s): Akito Tsukinaga [sup.1] , Takuma Maeda [sup.1] [sup.2] , Shunsuke Takaki [sup.3] , Nobuaki Michihata [sup.4] , Yoshihiko Ohnishi [sup.1] , Takahisa Goto [sup.5] Author Affiliations: (Aff1) 0000 0004 [...]