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Adipocyte Function in [IRS2.sup.-/-] Mice

Authors :
SMITH, JENNIFER
BURKS, DEBORAH J.
PERONI, ODILE
WITHERS, DOMINIC J.
ALTAMURO, SHARI
MYERS, MARTIN G.
LANNER, CARITA
DEPAOLI-ROACH, ANNA
KAHN, BARBARA B.
WHITE, MORRIS F.
Source :
Diabetes. May, 1999, Vol. 48 Issue 5, SA219
Publication Year :
1999

Abstract

Disruption of IRS1 in mice significantly retards growth (50-60%) but produces only mild insulin resistance. However, when IRS2 is disrupted, the animals are born with marked glucose intolerance upon birth [...]

Subjects

Subjects :
Diabetes -- Research
Health

Details

ISSN :
00121797
Volume :
48
Issue :
5
Database :
Gale General OneFile
Journal :
Diabetes
Publication Type :
Periodical
Accession number :
edsgcl.54771213