Identification and biochemical characterization of a novel nortriterpene inhibitor of the human lymphocyte voltage-gated potassium channel, Kv1.3

A study on the immunosuppression of voltage-gated delayed rectifier potassium channel called Kv1.3, found in human T lymphocytes, presents the initial biochemical characterization of correolide and several other structurally related molecules as inhibitors of Kv1.3. The experiment also reports on a radiolabeled correolide derivative, [3H]C20-29 dihydrocorreolide, which is useful as a ligand for the study of KV1 family channels. Results are discussed.