Effects an interactions of opioids on plasma exudation induced by cigarette smoke in guinea pig bronchi

Research was conducted to examine the effects of opioids on cigarette smoke-induced plasma exudation in vivo in the anesthetized guinea pig bronchi using Evans blue dye as a plasma marker. The objective was to determine whether the opioid receptor-selective agonists or morphine inhibited cigarette smoke-induced plasma exudation. Results indicate that cigarette smoke-induced mu-opioid-receptor agonists inhibit cigarette smoke-induced plasma exudation in the bronchi of guinea pigs in vivo.