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Activation of ERK by Ca2+ store depletion in rat liver epithelial cells
- Source :
- The American Journal of Physiology. Jan, 1999, Vol. 276 Issue 1, pC221, 1 p.
- Publication Year :
- 1999
-
Abstract
- The relationship between the extracellular signal-regulated protein kinase (ERK) and Ca2+ pool in rat liver epithelial cells was investigated. Results showed that ERK activity is increased by Ca2+ pool depletion induced by two independent methods. The first method involved the Ca2+ pool depletion by thapsigarin, while the second involved the addition of extracellular EGTA. Moreover, the increase in ERK activity by Ca2+ pool depletion was via the tyrosine kinase pathway.
Details
- ISSN :
- 00029513
- Volume :
- 276
- Issue :
- 1
- Database :
- Gale General OneFile
- Journal :
- The American Journal of Physiology
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.54222389