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Transcriptional repression by the Caenorhabditis elegans germ-line protein PIE-1
- Source :
- Genes & Development. Jan 15, 1999, Vol. 13 Issue 2, p202, 11 p.
- Publication Year :
- 1999
-
Abstract
- Transcriptional repression by a Caenorhabditis elegans germ-line protein has been studied. In the early C. elegans embryo, PIE-1 protein, which is maternally expressed, is necessary in germ-line blastomeres to inhibit somatic differentiation, block phosphorylation of the RNA polymerase II large subunit (Pol II) carboxy-terminal domain (CTD) and maintain mRNA transcription absence. It has been found the PIE-1 can act as a transcriptional repressor in cell culture assays. A PIE-1 repression domain that seems to cut back transcriptional machinery directly has been identified. It seems repressor activity may be important for in vivo PIE-1 function.
Details
- ISSN :
- 08909369
- Volume :
- 13
- Issue :
- 2
- Database :
- Gale General OneFile
- Journal :
- Genes & Development
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.53961931