Homozygosity mapping of a gene responsible for gelatinous drop-like corneal dystrophy to chromosome 1p

Research has determined a genetic locus for the autosomal recessive disorder gelatinous drop-like corneal dystrophy (GDLD), which causes amyloid deposits that impair vision. After linkage analyses were performed on affected Japanese subjects, homozygosity mapping placed the disease locus on the chromosome 1 short arm. Increased accuracy was obtained through haplotype analysis.