Mechanism of inhibition of Na+-bile acid cotransport during chronic ileal inflammation in rabbits

Na+-glucose cotransport has been previously demonstrated to be inhibited by a decline in the cotransporter numbers in rabbits, while Na+-amino acid cotransport was inhibited by a reduction in the affinity for the amino acid. It is further established that Na+-bile acid cotransport decreases in villus cells from the chronically inflamed ileum. In villus cell brush-border membrane vesicles from the chronically inflamed ileum, Na+-bile acid cotransport was also decreased, indicating a direct consequence of the cotransporter itself.