Stimulatory effect of insulin on creatine accumulation in human skeletal muscle

Research was conducted to examine the stimulatory effect of insulin on creatine accumulation in human skeletal muscle. The objectives were to determine whether insulin could stimulate in vivo creatine accumulation in human skeletal muscle, to determine at what plasma insulin concentration a response was evident and to examine whether an insulin-mediated increase in muscle blood blow was associated with any increase in muscle creatine accumulation. Results indicate that plasma creatine concentration was lower at several time points after the administration of insulin.