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Synthesis and incorporation of an N-acetylcysteamine analogue of methylmalonyl-CoA by a modular polyketide synthase
- Source :
- Journal of the American Chemical Society. Nov 4, 1998, Vol. 120 Issue 43, p11206, 2 p.
- Publication Year :
- 1998
-
Abstract
- Polyketides, which have a broad range of uses in human therapy, animal health and agriculture, have been known to be synthesized by using expensive coenzyme A thioesters used for chain extension. Large scale production of polyketides is therefore not economically feasible with the present method. A new truncated MeMalCoA derivative was synthesized in just one step and subsequently efficiently used as a substrate analogue by a module of the deoxyerythronolide-B synthase protein complex to produce a polyketide.
- Subjects :
- Enzymes -- Research
Proteins -- Research
Chemistry
Subjects
Details
- ISSN :
- 00027863
- Volume :
- 120
- Issue :
- 43
- Database :
- Gale General OneFile
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.53414480