Synthesis of phosphino oxazoline ligand libraries from amino acid and phosphino carboxylate building blocks

A modular route in generating ligands made from phosphine-containing acids and various amino acids employs an alkyl chain as a bridging structure connecting chelating functionalities. This allows the addition of a second chiral center next to the phosphine substituent. The resulting product is a diastereomeric ligand containing two chiral centers which can act either in concert or dissonance.