Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy

When the nuclear type of sterol regulatory element-binding protein-1c (nSREBP-1c/ADD1) is overexpressed in cultured 3T3-LI preadipocytes, adipocyte differentiation occurs. Transgenic mice with overexpression of nSREBP-1c in fat tissue have been produced under regulation of the adipocyte-specific aP2 enhancer/promoter. Disordered differentiation of fat tissue, insulin resistance of significance, diabetes mellitus and fatty liver from birth, with high plasma triglyceride levels later, were seen in a syndrome. Mice of this type have many of the same things seen in congenital generalized lipodystrophy (CGL).