Fluid overload and outcomes in neonates receiving continuous renal replacement therapy

Background Continuous renal replacement therapy (CRRT) has emerged as the modality of choice for the management of high-risk neonates with acute kidney injury (AKI), inborn errors of metabolism and multi-organ dysfunction. The aim of this study was to evaluate fluid overload (FO) and investigate the factors associated with outcomes in neonates undergoing CRRT. Methods We retrospectively reviewed the medical records of 34 neonates with AKI who were admitted to the neonatal intensive care unit (NICU) of Samsung Medical Center, Seoul, Republic of Korea between January 2007 and December 2014 where they underwent at least 24 h of CRRT. Results The survival rates of patients with an FO of [greater than or equal to]30 % at the time of CRRT initiation were lower than those of patients with an FO of Conclusions Neonates with a higher percentage FO and higher levels of serum creatinine at CRRT initiation showed poor outcomes. Early initiation of CRRT before the development of severe FO or azotemia might improve the outcomes of neonates requiring CRRT.
Author(s): Sang Taek Lee[sup.1] , Heeyeon Cho[sup.1] Author Affiliations: (1) Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, 135-710, Gangnam-gu, SeoulSouth Korea Introduction There has [...]