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Does caspase-12 suppress inflammasome activation?

Authors :
Walle, Lieselotte Vande
Fernandez, Daniel Jimenez
Demon, Dieter
Van Laethem, Naomi
Van Hauwermeiren, Filip
Van Gorp, Hanne
Van Opdenbosch, Nina
Kayagaki, Nobuhiko
Lamkanfi, Mohamed
Source :
Nature. June 2, 2016, pE1, 7 p.
Publication Year :
2016

Abstract

Inflammasomes are cytosolic protein complexes that activate caspase-1, an inflammatory protease that converts pro-interleukin (IL)-1β and IL-18 into their secreted, bioactive forms (1); and mechanisms regulating inflammasome activation have attracted [...]

Details

Language :
English
ISSN :
00280836
Database :
Gale General OneFile
Journal :
Nature
Publication Type :
Academic Journal
Accession number :
edsgcl.454485420
Full Text :
https://doi.org/10.1038/nature17649