Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth

Authors :: Zhang, Lin
Zhang, Siyuan
Yao, Jun
Lowery, Frank J.
Zhang, Qingling
Huang, Wen-Chien
Li, Ping
Li, Min
Wang, Xiao
Zhang, Chenyu
Wang, Hai
Ellis, Kenneth
Cheerathodi, Mujeeburahiman
McCarty, Joseph H.
Palmieri, Diane
Saunus, Jodi
Lakhani, Sunil
Huang, Suyun
Sahin, Aysegul A.
Aldape, Kenneth D.
Steeg, Patricia S.
Yu, Dihua
Source :: Nature. November 5, 2015, p100, 19 p.
Publication Year :: 2015
Abstract: The development of life-threatening cancer metastases at distant organs requires disseminated tumour cells' adaptation to, and co-evolution with, the drastically different microenvironments of metastatic sites (1). Cancer cells of common [...]

Subjects :: Gene mutations -- Identification and classification -- Health aspects
Gene expression -- Health aspects
Metastasis -- Genetic aspects
Disease susceptibility -- Genetic aspects
Environmental issues
Science and technology
Zoology and wildlife conservation

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