The metabolite α--ketoglutarate extends lifespan by inhibiting ATP synthase and TOR

Authors :: Chin, Randall M.
Fu, Xudong
Pai, Melody Y.
Vergnes, Laurent
Hwang, Heejun
Deng, Gang
Diep, Simon
Lomenick, Brett
Meli, Vijaykumar S.
Monsalve, Gabriela C.
Hu, Eileen
Whelan, Stephen A.
Wang, Jennifer X.
Jung, Gwanghyun
Solis, Gregory M.
Fazlollahi, Farbod
Kaweeteerawat, Chitrada
Quach, Austin
Nili, Mahta
Krall, Abby S.
Godwin, Hilary A.
Chang, Helena R.
Faull, Kym F.
Guo, Feng
Jiang, Meisheng
Trauger, Sunia A.
Saghatelian, Alan
Braas, Daniel
Christofk, Heather R.
Clarke, Catherine F.
Teitell, Michael A.
Petrascheck, Michael
Reue, Karen
Jung, Michael E.
Frand, Alison R.
Huang, Jing
Source :: Nature. June 19, 2014, Vol. 510 Issue 7505, p397, 18 p.
Publication Year :: 2014
Abstract: Metabolism and ageing are intimately linked. Compared with ad libitum feeding, dietary restriction consistently extends lifespan and delays age-related diseases in evolutionarily diverse organisms (1,2). Similar conditions of nutrient limitation [...]

Subjects :: Caenorhabditis elegans -- Genetic aspects
Adenosine triphosphate -- Properties
Metabolites -- Properties
Life spans (Biology) -- Genetic aspects
Environmental issues
Science and technology
Zoology and wildlife conservation

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